CGRP II, rat

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Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.

Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.

Calcitonin Gene Related Peptide (CGRP) II, rat induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC50 value of 0.56 nM.Calcitonin Gene Related Peptide (CGRP) II, rat relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC50 value of 83 μM.Calcitonin Gene Related Peptide (CGRP) II, rat (rβCGRP) inhibits [125I]hαCGRP binding (IC50: 7 nM), and stimulates cAMP accumulation (EC50: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor).Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC50 value of 2.8 nM approximately.

Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats. Animal Model:Male Sprague-Dawley rats.Dosage:0.01 ng/kg-3 μg/kg (100 μL), succeeded by a 150 μL isotonic saline flush, at 10 min intervals.Administration:A bolus injection Result:Induced PA (pial artery) dilatation and increased in LCBFFlux (local cortical cerebral blood flow).

Calcitonin Gene Related Peptide (CGRP) II, rat

Others

Other Targets

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99889-63-1

3805.31

C163H267N51O50S2

>98% (HPLC)

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Sequence:{Ser}{Cys}{Asn}{Thr}{Ala}{Thr}{Cys}{Val}{Thr}{His}{Arg}{Leu}{Ala}{Gly}{Leu}{Leu}{Ser}{Arg}{Ser}{Gly}{Gly}{Val}{Val}{Lys}{Asp}{Asn}{Phe}{Val}{Pro}{Thr}{Asn}{Val}{Gly}{Ser}{Lys}{Ala}{Phe}-NH2 (Disulfide bridge: Cys2-Cys7)

(-20℃)

With Ice Pack

≥ 2 years